R&D

SMART DRUG DELIVERY PLATFORM
BASED ON CELL-DERIVED VESICLES

Core Technology

At MDimune, we are passionate about changing the world by developing innovative therapeutics.

  • Large-scale production of
    therapeutic vesicles     from cells
    using direct extrusion method

    Exosomes are nanosized vesicles naturally released from various types of cells, including immune cells and stem cells. Exosomes have garnered broad attention as a next-generation drug delivery system with their roles in various intercellular communications. However, a minuscule quantity of exosomes has been a drawback for commercialization.

    MDimune Inc. developed the BioDrone® Technology for producing cell-derived vesicles (CDVs, exosome mimetics) in a large quantity from various cell sources by extrusion method. MDimune Inc. is currently optimizing this innovative platform technology to tackle various human diseases.

  • Targeted drug delivery platform
    that minimizes side effects and
    maximizes efficacy

    As drone delivery will likely transform courier services by providing speedy and accurate package delivery, the human cell-derived vesicle(CDV)-based drug delivery platform, BioDrone® Technology, will enable highly targeted drug delivery to specific lesions by utilizing immune cell- and stem cell-derived vesicles loaded with drugs. The innovative target-specific delivery by BioDrone® Technology will minimize side effects and maximize the efficacy of drugs by using minimal doses.

  • Stem cell-derived vesicles as
    innovative therapeutics for
    treating incurable diseases

    By combining the regenerative potential of stem cells with proven efficacies of various drugs loaded in the vesicles, these novel therapeutics based on stem cell-derived vesicles will provide synergistic effects for treating incurable diseases.

  • BioDrone® Technology utilizes
    cells from diverse human
    tissues and transformed cells

    Versatility is one of the compelling advantages of our direct extrusion technology. By utilizing various types of human cells from different organs as well as cells transformed to harbor specific traits, we can produce vesicles delivering drugs to desired targets. MDimune Inc. is currently collaborating with pharmaceutical companies who are interested in applications of the BioDrone® Technology in various unmet medical needs.

  • Cell-Derived Vesicles (CDVs)
    vs Exosomes

    CDVs are a next-generation drug development platform technology. CDVs are similar to exosomes in size, properties, and functions but exhibit substantial advantages through large-scale production and versatility of using various cell types.

Patents

NO Patent name Application/
Registration		 Application/Registration
Number		 Country Registration
Date
18 세포 내 흡수능이 증대된 세포 유래 베시클 및 이의 제조 방법
Cell derived vesicle with enhancing uptake ability and method for manufacturing the same		 10-2506995 한국
KR		 2023.03.02
17 세포 유래 베시클을 이용한 침샘 질환 예방 또는 치료용 조성물
Composition for preventing or treating salivary gland disease comprising cell derived vesicles		 10-2506986 한국
KR		 2023.03.02
16 성체줄기세포 유래의 나노베시클 및 이의 표적 치료용 용도
Nanovesicles from Adult Stem Cells and its use for targeted therapy		 10-2223374 한국
KR		 2021.02.26
15 성체줄기세포 유래의 나노베시클 및 이의 표적 치료용 용도
Nanovesicles from Adult Stem Cells and its use for targeted therapy		 10-2184722 한국
KR		 2020.11.24
14 간엽줄기세포 유래 인공나노좀을 포함하는 폐질환 예방 또는 치료용 약학적 조성물
Pharmaceutical composition for preventing or treating of pulmonary disease comprising mesenchymal stem cell-derived artificial nanosomes		 10-2035716 한국
KR		 2019.10.17
13 단백질 항상성 조절인자가 풍부한 세포 유래 베시클 및 이의 제조 방법
Protein homeostasis regulator enriched cell derived vesicle and method for manufacturing the same		 10-2236375 한국
KR		 2021.03.30
12 세포 유래 베시클 제조 방법 및 이의 활용
Cell-derived vesicle manufacturing method and use thereof		 10-2236372 한국
KR		 2021.03.30
11 세포 압출기 및 세포 압출방법
Cell extruder and Cell extrusion method		 10-2142479 한국
KR		 2020.08.03
10 분산성이 우수한 세포 압출장치 및 이를 이용한 세포 압출방법
CELL EXTRUDING APPARATUS WITH EXCELLENT DISPERSIBILITY AND EXTRUSION METHOD THEREOF		 10-2154135 한국
KR		 2020.09.03
9 멤브레인 모듈을 포함하는 세포 압출장치 및 이를 이용한 세포 압출방법
CELL EXTRUDING APPARATUS COMPRISING MEMBRANE MODULE AND EXTRUSION METHOD THEREOF		 10-2134906 한국
KR		 2020.07.10
8 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도
Microvesicles derived from nucleated, mammalian cells and use thereof		 10,675,244 미국
US		 2022.06.09
7 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도
Microvesicles derived from nucleated, mammalian cells and use thereof		 EP2450032 프랑스
FR		 2018.09.05
6 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도
Microvesicles derived from nucleated, mammalian cells and use thereof		 EP2450032 영국
GB		 2018.09.05
5 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도
Microvesicles derived from nucleated, mammalian cells and use thereof		 2450032 유럽
EP		 2018.09.05
4 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도
Microvesicles derived from nucleated, mammalian cells and use thereof		 60 2010 053 375.1 독일
DE		 2018.09.05
3 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도
Microvesicles derived from nucleated, mammalian cells and use thereof		 5667180 일본
JP		 2014.12.19
2 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도
Microvesicles derived from nucleated, mammalian cells and use thereof		 ZL201080037538.X 중국
CN		 2014.05.28
1 포유류의 유핵세포에서 유래된 마이크로베 시클 및 이의 용도
Microvesicles derived from nucleated, mammalian cells and use thereof		 10-1314868 한국
KR		 2013.09.27